李景振,曾 宁,聂泽东,刘宇航.无创血糖检测中不同葡萄糖浓度的介电- 频率响应特性研究[J].集成技术,2019,8(2):66-75
无创血糖检测中不同葡萄糖浓度的介电- 频率响应特性研究
Investigation on Dielectric-Frequency Response Characteristics ofGlucose Solution with Different Concentrations for Noninvasive BloodGlucose Monitoring
  
DOI:10.12146/j.issn.2095-3135.20181114001
中文关键词:  无创血糖检测;介电-频率特性;葡萄糖浓度;Debye 模型
英文关键词:noninvasive blood glucose monitoring; dielectric-frequency response; glucose concentration; Debye model
基金项目:国家自然科学基金项目(61871375、U1505251);国家重点研发计划项目(2018YFC2001002) 作者简介:李景振,硕士,研究方向为射频信号的传输与传感、图像处理等;曾宁,硕士研究生,研
作者单位
李景振 中国科学院深圳先进技术研究院 深圳 518055 
曾 宁 中国科学院深圳先进技术研究院 深圳 518055;汕头大学 汕头 515063 
聂泽东 中国科学院深圳先进技术研究院 深圳 518055 
刘宇航 中国科学院深圳先进技术研究院 深圳 518055 
摘要点击次数: 211
全文下载次数: 1151
中文摘要:
      无创血糖检测技术具有无痛感、不易感染和可连续监测等优点,是血糖检测技术发展的重要 方向。为了研究在不同频率下、不同葡萄糖浓度对介电特性的影响,该文首先以不同葡萄糖浓度的 水溶液为研究对象,探索了 500 kHz~5 MHz 频率范围内不同葡萄糖浓度水溶液的介电-频率特性。 研究表明,葡萄糖水溶液在 500 kHz~5 MHz 的响应特性与高频下的响应特性不同。在该频段下,当 葡萄糖浓度不变时,水溶液的复介电常数的实部和虚部随着频率的增大而减小;当频率不变时,水 溶液的复介电常数的实部和虚部随着葡萄糖浓度的增大而减小。其次,该文还通过对复介电常数测量 值进行二阶 Debye 模型拟合,并对 Debye 模型中的参数进行了二次多项式拟合。拟合的决定系数均 高于 0.93,最终得出了葡萄糖浓度为 0~16% 水溶液的复介电常数在不同葡萄糖浓度和频率下的相关 函数,量化了葡萄糖水溶液的复介电常数与葡萄糖浓度及频率的关系。最后,通过建立包含皮肤、血 液、肌肉的无创血糖检测模型,并采用基于时域有限差分法对模型进行仿真分析。结果表明,接收电 极 2 与 3 之间的电压差值随着葡萄糖浓度的增加而线性增大,为基于 500 kHz~5 MHz 频率范围内的 无创血糖检测提供了一定的理论基础。
英文摘要:
      Noninvasive blood glucose monitoring technology has advantages of painlessness, no infection, and continuous detection, which is an important direction for the development of blood glucose monitoring technology. In order to explore the effects of frequency and glucose concentration on the dielectric properties, the dielectric-frequency characteristics of aqueous solutions with different glucose concentrations are investigated in the frequency range of 500 kHz to 5 MHz. The results show that when the glucose concentration is constant, the real and imaginary parts of the complex permittivity of the aqueous solution decrease in this frequency band as the frequency increases. When the frequency is constant, the real and imaginary parts of the complex permittivity of the aqueous solution decrease as the glucose concentration increases. The results are different from that in high frequency. In addition, the second-order Debye model fitting of the complex permittivity of aqueous solution and the quadratic polynomial fitting of the parameters in the Debye model are studied in this paper. The determination coefficient of all fitting is higher than 0.93, indicating that the model can better represent the dielectric-frequency response characteristics of glucose solution with different concentrations. Finally, a noninvasive blood glucose monitoring model which consists of skin, blood and muscle, was established and the simulation was carried out through finite-difference time-domain. The results indicate that the voltage difference between receiving electrode 2 and 3 increases linearly with the increasing of glucose concentration. We therefore suggest that the proposed frequency between 500 kHz and 5 MHz is feasible in the applications of noninvasive blood glucose monitoring.
查看全文  查看/发表评论  下载PDF阅读器
关闭
微信关注二维码 用微信扫一扫

美女

美女图片

美女

美女图片