CD317 在肿瘤发生发展及治疗方面的研究进展
CD317 在肿瘤发生发展及治疗方面的研究进展
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国家自然青年科学基金项目(81701559);深圳市科技计划基础研究项目(JCYJ20170818155135838);广东省免疫细胞治疗工程技术 研究中心项目(粤科函产学研字【2018】2580 号)

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Research Progress of CD317 in Tumor Development and Treatment
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National Natural Science Foundation of China(81661168015, 81871447);Shenzhen Science and Technology Innovation Commission Project(ZDSYS201703031711426)

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    摘要:

    CD317(Tetherin、BST-2 或 HM1.24)是由 BST-2 基因编码的一个结构独特的 II 型跨膜糖蛋白, 在多种人体组织中组成型表达,也可被干扰素等细胞因子诱导。近年来,越来越多的研究表明,CD317 在多种肿瘤中表达上调,广泛参与肿瘤细胞增殖、迁移以及凋亡抵抗等生物学过程从而促进肿瘤的发 生发展,是肿瘤治疗的潜在靶点。该文聚焦肿瘤领域,总结 CD317 的表达模式、作用机制以及靶向策 略的相关进展,为肿瘤发病理论研究、治疗策略开发提供新的思考和方向。

    Abstract:

    CD317 (Tetherin, BST-2 or HM1.24), encoded by the BST-2 gene, is a type II transmembrane glycoprotein with a unique topology. CD317 is constitutively expressed in a variety of human tissues, and can also be induced by some cytokines such as interferon. Recently, many studies have shown that CD317 is overexpressed in different types of tumors with critical roles to facilitate tumor progression by regulating multiple biological processes, such as proliferation, migration and apoptosis. Therefore, CD317 is suggested as a promising target for tumor therapy. This review focuses on the research progress of CD317 in tumor development, including its expression within tumors, mechanisms for tumorigenesis, and potential as a target against cancer, and will hopefully provide novel ideas and direction for discovering tumorigenesis is overexpressed in different types of tumors with critical roles to facilitate tumor progression by regulating multiple biological processes, such as proliferation, migration and apoptosis. Therefore, CD317 is suggested as a promising target for tumor therapy. This review focuses on the research progress of CD317 in tumor development, including its expression within tumors, mechanisms for tumorigenesis, and potential as a target against cancer, and will hopefully provide novel ideas and direction for discovering tumorigenesis mechanisms and new therapeutic strategies.

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引文格式
万晓春,章桂忠,邓 湉,陈 倩. CD317 在肿瘤发生发展及治疗方面的研究进展 [J].集成技术,2020,9(6):1-12

Citing format
WAN Xiaochun, ZHANG Guizhong, DENG Tian, CHEN Qian. Research Progress of CD317 in Tumor Development and Treatment[J]. Journal of Integration Technology,2020,9(6):1-12

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  • 在线发布日期: 2020-11-24
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