国家重点研发计划项目(2018YFA0902701)；中国科学院战略重点研究计划项目(XDB29050501, XDPB18)；国家自然科学基金项目(32025022, 3201101136)；深圳市科技创新委员会项目(KQTD2015033117210153, JCYJ20170818164139781)
National Key R & D Program of China (2018YFA0902701), Strategic Priority Research Program of Chinese Academy of Sciences (XDB29050501, XDPB18), National Natural Science Foundation of China (32025022, 3201101136), Shenzhen Science Technology and Innovation Commission (KQTD2015033117210153, JCYJ20170818164139781)
In recent years, research on the intestinal microbial communities and human health has developed rapidly. However, the regulation and application of the intestinal microbial community are still in their infancy. The reason for this is that our understanding of the structure and function of the human gut microbiome is inadequate. Synthetic microbiota is a new microbial community established by artificial synthesis of multiple species, which is simulated, tested, and optimized by various experimental models and mathematical modeling methods in vitro and in vivo. It is helpful to deepen the understanding of the structure, stability, and functional activity of the complex microbiota in the human gut. We summarized the research methods of the intestinal microbiome, the factors affecting the stability of the intestinal microbiome, and the challenges facing the synthesis of the intestinal microbiome, in order to provide a reference for the bidirectional transformation of the theoretical research and clinical application of intestinal microbial community.
胡 政,周 茜,张蒙蒙,肖敏凤.肠道微生物群落研究进展及合成微生物群落面临的挑战 [J].集成技术,2021,10(4):102-114
HU Zheng, ZHOU Qian, ZHANG Mengmeng, XIAO Minfeng. Advances in Intestinal Microbial Communities and Challenges in Synthetic Microbial Communities[J]. Journal of Integration Technology,2021,10(4):102-114