脑干蓝斑到前庭神经核的神经环路投射及在压力应激下的激活研究
脑干蓝斑到前庭神经核的神经环路投射及在压力应激下的激活研究
作者:
作者单位:

作者简介:

通讯作者:

基金项目:

国家自然科学基金委员会面上项目(31971072, 31471109);广东省国际合作项目(2019A050510032);深圳市科技创新委员会项目

伦理声明:



The Activation of Locus Coeruleus Under Stress and Its Norepinephrine Projection to Vestibular Nuclei
Author:
Ethical statement:

Affiliation:

Funding:

National Natural Science Foundation of China (31971072, 31471109), Guangdong International Cooperation Grant (2019A050510032), Shenzhen Science Technology and Innovative Commission (JCYJ20180508152336419) and Key-Area Research and Development Program of Guangdong Province (2018B030331001)

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
    摘要:

    前庭神经核(Vestibular Nuclei)是保持平衡的关键核团,其功能异常与晕动病、前庭偏头痛、帕 金森氏病等多种疾病状态密切关联,压力应激往往加重以上疾病的症状并伴随着蓝斑(Locus Coeruleus) 去甲肾上腺素能系统的激活。该研究利用转基因小鼠结合病毒示踪显示从蓝斑到前庭神经核的神经投 射,并利用酪氨酸羟化酶(Tyrosine Hydroxylase)抗体免疫荧光染色确定蓝斑-前庭神经核的投射为去甲 肾上腺素能。结果显示,小鼠在睡眠剥夺压力刺激下蓝斑去甲肾上腺素能神经元被强烈激活,而前庭 神经核神经元激活不明显,提示睡眠剥夺可能通过蓝斑-前庭神经核的去甲肾上腺素能神经调制起作 用。该结果可为继续探究蓝斑-前庭神经核神经环路在压力应激与前庭神经核功能调控之间的重要作用 提供解剖结构学基础。

    Abstract:

    Vestibular nuclei (VN) is a sensorimotor structure controlling posture and balance. The anatomy and function of VN is closely related to diseases, such as motion sickness, vestibular migraine, vertigo, postural deficits, and Parkinson’s disease. It has been known that stress imposes effects on the function of VN and the progress of these diseases. Since the locus coeruleus-norepinephrine (LC-NE) system is activated by stress, it would be interesting to know whether there is a connection between LC and VN and its possible function. The experiment results showed that LC neurons project to the VN and they are tyrosine hydroxylase (TH)-positive. After subjected to sleep deprivation stress treatment, the mice showed higher cFos activation in the LC-NE neurons compared with the untreated control group, suggesting the important role LC-NE may play in stress-related VN malfunction. This study provides anatomical basis for further neural circuity studies of LC-VN in balance and then its possible involvement in diseases.

    参考文献
    相似文献
    引证文献
引用本文

引文格式
魏梦霞,纪树钦,李子杰,林子逸,MONTARDY Quentin,王立平,李蕾.脑干蓝斑到前庭神经核的神经环路投射及在压力应激下的激活研究 [J].集成技术,2021,10(5):12-22

Citing format
WEI Mengxia, JI Shuqin, LI Zijie, LIN Ziyi, MONTARDY Quentin, WANG Liping, LI Lei. The Activation of Locus Coeruleus Under Stress and Its Norepinephrine Projection to Vestibular Nuclei[J]. Journal of Integration Technology,2021,10(5):12-22

复制
分享
文章指标
  • 点击次数:
  • 下载次数:
  • HTML阅读次数:
历史
  • 收稿日期:
  • 最后修改日期:
  • 录用日期:
  • 在线发布日期: 2021-09-15
  • 出版日期: