沈洋,凌涛,姚惠,李彦明,靳巧锋,郑海荣.超声瞬时弹性成像算法与系统设计[J].集成技术,2012,1(1):93-99
超声瞬时弹性成像算法与系统设计
Imaging Algorithm and System Design for Ultrasound Transient Elastography
  
DOI:
中文关键词:  超声瞬时弹性成像;互相关;匹配滤波器;时间增益补偿;生物仿体;剪切波
英文关键词:ultrasonic transient elastography; cross-correlation; match filter; time gain compensation; tissue-mimicking phantom; shear wave
基金项目:
作者单位
沈洋 中国科学院深圳先进技术研究院 深圳 518055 
凌涛 中国科学院深圳先进技术研究院 深圳 518055 
姚惠 中国科学院深圳先进技术研究院 深圳 518055 
李彦明 中国科学院深圳先进技术研究院 深圳 518055 
靳巧锋 中国科学院深圳先进技术研究院 深圳 518055 
郑海荣 中国科学院深圳先进技术研究院 深圳 518055 
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中文摘要:
      超声瞬时弹性成像技术具有无创、无痛、定量、实时及重复性好等优势,适用于肝纤维化分期诊断,具有重要的临床应用价值。本文以超声瞬时弹性成像系统设计为研究出发点,提出在基于射频信号的时域互相关算法基础上,采用抛物线插值算法提取亚采样信息,提高位移场的估算精度;设计了剪切波匹配滤波器,以减弱低频振荡器对位移场造成的干扰,从而提高了应变估计质量,增强了剪切波速度估算的可靠性与准确性;设计了针对瞬时弹性成像系统的时间增益补偿(TGC)电路,以降低声信号衰减带来的影响,提高信号的信噪比;给出了一种聚丙烯酰胺凝胶生物仿体的制备方法,并采用机械压痕测试对仿体进行标定,将标定结果与瞬时弹性成像系统的检测结果进行了对比,对比结果显示出良好的一致性。生物仿体实验和健康人体肝脏的弹性测量结果也验证了提出的位移估计算法、匹配滤波器及TGC电路的优越性。
英文摘要:
      For the advantages of noninvasive, real-time and quantitative detection, ultrasonic transient elastography has important clinical application value. This work investigates the transient elastography in a few ways and aims to design a transient imaging system. The Displacement tracking algorithm based on correlation techniques and the parabolic interpolation algorithm is proposed to improve the accuracy. A novel match filter is designed to convolute with the estimated displacement in the time direction to boost the SNR of the displacement for a better strain image mapping. The convoluted result shows the match filter can significantly improve the strain image quality and help getting more accurate Youngs modulus estimation. The Time Gain Compensation (TGC) circuit is designed to compensate the attenuated power of the ultrasound signal. And a modified polyacrylamide gel based tissue-mimicking phantom is also developed in this paper, both indentation testing and transient elastography are used to characterize the elastic properties of this phantom. The results are almost consistent with each other.
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