• The rapid development of biomaterials and biotechnology has provided important means for revealing life phenomena and life processes, which is the basis for tissue and organ regeneration and reconstruction, and so is the catalyst for a second life. This special issue “Development and Exploration of Biomaterials in Shenzhen” has published wonderful reports and extended content of the 2021 Shenzhen Biomedical Materials Annual Conference, so that the readers who were unable to attend due to the COVID-19 epidemic could also take a glimpse of this annual conference via the special issue. [MORE]
  • The ocean plays an important role in the future development. The Shenzhen Institute of Advanced Technology(SIAT), Chinese Academy of Sciences has deeply involved in the field of marine science. This special issue introduces recent research of SIAT’s team, covering marine engineering technology, underwater acoustic technology, underwater wireless transmission technology, marine biochemical sensing technology and seawater desalination technology, etc. In addition, low-power marine instrument recovery communication beacons developed by Professor Yang Ting’s team [MORE]
  • Advanced electronic material is one of the three main elements of integrated circuit and is the foundation and support of electronic information industry. Trade frictions occurred in recent years fully illustrate the strategic importance of materials, especially electronic materials used in integrated circuit industry. In this context, we specially invited Professor Rong Sun, director of the Shenzhen Institute of Advanced Electronic Materials, as the guest editor to organize the special issue focused on high-end electronic packaging materials for integrated circuit [MORE]
  • In recent years, the Chinese government has provided strong support for new energy vehicles and intelligent connected vehicles in terms of scientific and technological research, industrial development, application demonstration, and market promotion. Interestingly, China has become one of the most active countries in the field of new energy vehicles. Although the new energy vehicle industry has shown a good momentum in China, it has to overcome core technological barriers. [MORE]
  • With the rise of 5G communication, Internet of Things, new energy automotive electronics, wearable devices, and smart cities, affiliated electronic devices are developing towards the directions of miniaturization, high-power density, and multi-functionality. This will continue to increase the risk of overheating with related electronic devices. The development of high-performance thermal management materials is crucial to improve the heat dissipation of electronic devices, and it has become the biggest challenge faced by academia and application industry in electronic devices. [MORE]
  • Recently, with the maturity and popularization of technologies such as Internet of Things, cloud computing, mobile internet, and Internet of Vehicles, massive data in various formats like images, audiovisual materials, and health files are rapidly generated. The International Data Corporation (IDC) predicted that global data volume would reach 175 ZB (approximately 175 billion TB) by 2025, which indicated that more than 99% of all data in human civilization were generated in recent years. [MORE]
  • This special issue majorly reports the research exploration made by the key members from Guangdong Innovation Team of Advanced Functional Film Materials and Industrial Applications, which includes the analysis and discussion of preparation methods and growth mechanism of high-preferred orientation diamond film and high-quality single crystal diamond, the research of diamond film in cemented carbide tools, the latest research progress on film thermal expansion coefficient and residual stress testing technology. [MORE]
  • Big data is leading a new round of technological innovation, and it has brought new impetus and opportunities for the transformation and upgrading of social economy and the enhancement of national competitiveness. Therefore, many countries have proposed initiatives to develop big data. In recent years, big data has triggered extensive studies in a variety of disciplines and brought changes in terms of technology, model and ideology to different industries. The special issue was organized around big data platforms and supporting technologies, and big data applications, security and privacy [MORE]
  • Intelligent connected vehicles are equipped with advanced on-board sensors, controllers, actuators and other devices, and integrate modern communication and network technologies to realize information sharing between vehicles, roads, people, and clouds to achieve "safe, efficient, comfortable and energy-saving" driving. Although the industry shows a positive trend of comprehensive development, it is facing several technical adjustments on core technology level, including bicycle perception and decision-making, vehicle-road cooperation, human-machine co-driving [MORE]
Journal of Integration Technology (CN 44-1691/T, ISSN 2095-3135) is a peer-reviewed open-access journal published bi-monthly. It focuses on multidisciplinary integration especially involved in the fields of information technology, biotechnology, new energy and new materials. Its publishing scope includes but is not limited to the big data, artificial intelligence, computer, synthetic biology, brian science, biomedicine, biomedical engineering, new energy, advanced materials, smart driving, smart city, internet of things, electric vehicles, ocean technology. [MORE]
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    Volume 14, No. 1 | 2025
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    • LI Guojie

      2025,14(1):1-8, DOI: 10.12146/j.issn.2095-3135.20241215001

      Abstract:

      Mainstream artificial intelligence technology can be viewed as “intelligent computing technology” from one perspective. This article presents some views on the historic breakthroughs, development trends, and challenges faced by intelligent computing technology. It also provides a brief overview of commonly concerned issues such as whether the scaling law has reached its ceiling, where the solution to the shortage of computing power lies, and what the essence of large models is.

    • WU Fuxiang, CHENG Jun

      2025,14(1):9-24, DOI: 10.12146/j.issn.2095-3135.20241201002

      Abstract:

      In recent years, the rapid development of generative AI has made text-driven video prediction large models a hot topic in academia and industry. Video prediction and generation should address temporal dynamics and consistency, requiring precise control of scene structures, subject behaviors, camera movements, and semantic expressions. One major challenge is accurately controlling scene dynamics in video prediction to achieve high-quality, semantically consistent outputs. Researchers have proposed key control methods, including camera control enhancement, reference video control, semantic consistency enhancement, and subject feature control improvement. These methods aim to improve generation quality, ensuring outputs align with historical context while meeting user needs. This paper systematically explores the core concepts, advantages, limitations, and future directions of these four control approaches.

    • XU Qinglin, QIAO Yu, WANG Yali

      2025,14(1):25-38, DOI: 10.12146/j.issn.2095-3135.20231225001

      Abstract:

      The domain gap between dark scenes and the data used by traditional pretrained models leads to suboptimal performance with the conventional pretrain-finetune approach, and pretraining from scratch is costly. To address this issue, a domain-adaptive pretraining method is proposed to improve action recognition performance in the dark environments. The method integrates an external vision enhancement model for de darkening to introduce critical knowledge for dark scene processing. It also employs a cross-domain self distillation framework to reduce the domain gap of visual representations between illuminated and dark scenes. Through extensive experiments in various dark environment action recognition settings, the proposed approach can achieve a Top1 accuracy of 97.19% on the dark dataset of fully supervised action recognition. In the source-free domain adaptation on the Daily-DA dataset, the accuracy can be improved to 49.11%. In the multi source domain adaptation scenario on the Daily-DA dataset, the Top1 accuracy can reach 54.63%.

    • XIE Zhijun, ZHAO Canming, KE Xin, XIAO Yang, WU Jing, SONG Jialei

      2025,14(1):39-49, DOI: 10.12146/j.issn.2095-3135.20240312002

      Abstract:

      The paper designed a compact, low-cost, and efficiently swimming small, single-jointed bionic robotic fish based on the propulsion mode and fin modularity of trevally fish, with easy disassembly of the pectoral, ventral, and caudal fins. In addition, the paper conducted underwater experiments on the straightline propulsion, static turning, and head stability of the bionic robotic fish, and investigated the effects of the pectoral and ventral fins on the swimming performance. In the swimming test of the prototype, the paper utilizes a high-speed camera and a plane mirror to construct a “binocular vision system” to record the movement of the fish, which can track the most anterior part of the fish head and two marking points above the prime point, and record the three-dimensional position information. This can provide a reference for quantitative analysis of swimming performance, attitude change and head stability performance. The results showed that the straight-line propulsion and turning performance of the robotic fish was better; in the stability experiment, the robotic fish equipped with pectoral and ventral fins had better head stability in low-frequency swimming, while it did not show an advantage in high-frequency swimming, which was consistent with the phenomenon that various fins except the caudal fin stick to the body in high-frequency swimming of fishes in nature.

    • ZHANG Mingkai, GU Feifei, XIAO Zhenzhong, SHI Shaoguang

      2025,14(1):50-64, DOI: 10.12146/j.issn.2095-3135.20240820001

      Abstract:

      The accurate reconstruction of industrial component edges is essential and crucial for visual positioning and quality inspection. To address the issue of difficulty in accurately reconstructing point clouds at the edges of industrial components, a three-dimensional edge reconstruction algorithm based on point cloud projection is proposed. First, the three-dimensional point cloud of the components is obtained by scanning using a binocular structured light method, edge points in the scanned point cloud are extracted. Then the image edge points are extracted from the binocular images. Subsequently, the point cloud edge points are projected onto the binocular images, the nearest image edge points are searched around each projected point to obtain corresponding binocular edge points. Finally, accurate three-dimensional edge point clouds are reconstructed using stereo vision methods. Experimental results demonstrate that compared to other current methods, this approach can effectively address the issue of false edges caused by interference such as reflection and surface scratches, the reconstructed edge point cloud using this method has high accuracy with reconstruction error less than 0.15 mm and can be applied in industrial scenarios such as bin picking, online quality inspection.

    • XU Tao, WANG Shuncheng, ZHONG Jianwen, LIU Dabo, ZHOU Yilong, LIU Chang

      2025,14(1):65-77, DOI: 10.12146/j.issn.2095-3135.20240307001

      Abstract:

      Adenoid hypertrophy (AH) is a key contributor to pediatric obstructive sleep apnea syndrome (OSAS). Physicians rely on nasopharyngeal endoscopy to identify AH and the obstruction of adenoid to the airway. However, due to the limitations of 2D endoscope images, physicians have to subjectively infer the 3D structure of the adenoid region, which heavily relies on their expertise and the angle at which the adenoids are observed. The adenoid surface is composed of mucosal tissue covered by nasal secretions, and thus strongly reflective, smooth, and lack features. Furthermore, the endoscope image of adenoid is relatively blurred. Based on these unique characteristics of the adenoids, this paper introduces a multi-view stereo algorithm based on endoscopic image sequences of the adenoid nasopharyngeal cavity. The algorithm employs multi view stereo matching to first estimate the depth maps corresponding to the images. Subsequently, it utilizes mesh surfaces to fit the rough depth information in the depth space, and thereby generates the smooth and refined depth maps. Eventually, fusing the obtained depth maps leads to a dense and precise reconstruction of the adenoid region. Both synthetic and real experimental results demonstrate that the algorithm can achieve accurate, dense, and smooth reconstruction of the adenoid area, surpassing the existing reconstruction algorithms significantly.

    • XIONG Shaokui, CHEN Shifeng

      2025,14(1):78-90, DOI: 10.12146/j.issn.2095-3135.20240422001

      Abstract:

      In this work, a visual language model is introduced in ophthalmic image disease recognition. And a multi-disease recognition algorithm based on a pre-trained contrasting language-images model is proposed. First, a multi-labeled fundus image dataset MDFCD8 containing 8 categories is constructed based on several publicly available fundus image datasets. Then, the generative artificial intelligence GPT-4 (Generative Pre-trained Transformer 4) is utilized to generate expert knowledge describing the fine-grained pathological features of fundus images, which solves the problem of the lack of text labels in fundus image datasets. The paper calculates the average precision (AP), F1 score, and area under the receiver operating characteristic curve (AUC), and takes the mean value of the three as the final performance evaluation index. The experimental results showed that, the method proposed in this paper outperforms the traditional convolutional neural network and Transformer network by 4.8% and 3.2%, respectively. This study also conducted ablation experiments on each module to validate the effectiveness of the method, demonstrating the potential application of visual language modeling in the field of auxiliary diagnosis of ophthalmic diseases.

    • KONG Weikun, ZHONG Cheng, CHEN Wenbo, YU Shuhui, SUN Rong

      2025,14(1):91-104, DOI: 10.12146/j.issn.2095-3135.20240119001

      Abstract:

      Against the backdrop of Moore’s Law approaching its limits and the increasing difficulty and cost of next-generation integrated circuit technologies, advanced substrate technology emerges a crucial carrier for supporting I/O enhancementand system integration in the realm of advanced packaging. It is also one of the core components in the post-Moore era. Currently, semi-additive process utilizing build-up film (BF) is one of theprimary methods for achieving fine-pitch multilayer packaging substrates. Given the increasingly prominent issue of signal integrity in electronic equipment operating in high-frequency and high-speed environments, this paper thoroughly discusses the impact of the physical properties of BF material and structural characteristics on signal transmission loss. Based on typical substrate structures, such as microstrip lines and vias, the relationship between BF material parameters and signal transmission performance is studied using an electrical simulation analysis system. It is found that in a microstrip structure, the signal transmission loss increases with an increase in frequency, and this loss is closely related to the dielectric loss factor of BF material. However, in the via structure, the dielectric constant of the BF material significantly influences the equivalent capacitance and the value of impedance, subsequently affecting impedance mismatch. Although the characteristics of the BF material do have some impact on impedance mismatch, the primary factor affecting impedance matching remains the design of via structure itself. In addition, the conductor loss resulting from the skin effect increases with the rise in copper foil roughness at high frequency, offering a crucial reference for quality control of copper foil during the manufacturing process of packaging substrate. This study elucidates the mechanism of physical property and structural characteristics of BF material influencing signal transmission loss, thereby proving a theoretical foundation for the design and optimization of BF material with enhanced physical properties for packaging substrate.

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    The "In Press" section displays the articles officially accepted after peer review. These articles are currently under copyediting process without volume/issue information, but are citable according to their Digital Object Identifiers(DOI).

    • huanglingfeng,Yang ⑩long,Xie Yaoqin

      Doi: 10.12146/j.issn.2095-3135.20241129001

      Abstract:

      As a vital part of traditional Chinese medicine, acupuncture has broad global applications. However, the reliance on practitioners'' experience for acupoint localization in traditional acupuncture methods leads to a lack of standardization, restricting its reproducibility and broader adoption. Acupuncture robots, as intelligent medical devices, offer new opportunities for standardizing and promoting acupuncture techniques. This paper introduces an improved YOLOv8-Pose model, YOLO-PointMap, designed to address challenges in dense acupoint distribution and weak feature recognition. By incorporating dynamic convolution to optimize the C2f module and introducing a channel-attention-based feature fusion module, the model achieves significant advancements in multi-scale feature extraction and integration. Experimental results show that the EPE, PCK and mAP50-95 (Pose) indexes of YOLO-PointMap on the test set are superior to the existing methods, with the values reaching 3.27, 1 and 84.9% respectively, especially in dense key point identification and weak feature region localization. It provides strong support for the development of acupuncture robot technology, and shows the potential application value in the fields of virtual reality and intelligent interaction.

    • zhang jieyang,He Shuai,Deng Zhen

      Doi: 10.12146/j.issn.2095-3135.20240926001

      Abstract:

      Flexible robotic endoscopy have been employed in minimally invasive surgeries, however the non-linear deformable characteristics of the flexible endoscope complicate its control. This paper proposes an optimal teleoperation control method for flexible robotic endoscopy using neurodynamic optimization. A master-slave motion mapping strategy is designed in image space and the kinematic model of the flexible endoscope is established based on the constant curvature assumption. It obtains the mapping relationship between image feature velocity and actuation velocity. Considering robot physical constraints, an optimal control problem based on quadratic programming (QP) is constructed. A neurodynamic optimization method is designed to solve the complex QP problem. Experiments were conducted on a ureteroscope robot system to validate the effectiveness of the method. Experimental results indicate that the proposed method can significantly reduce human control errors and vibrations, maintaining target point tracking precision within 2.5%. The feasibility of the proposed method in ureteroscopic lithotripsy was also verified.

    • WANG HERAN,XIE JIXIONG,ZHU JIONGTAO,ZHANG XIN,TAN YUHANG,SU TING,GE YONGSHUAI

      Doi: 10.12146/j.issn.2095-3135.20241021001

      Abstract:

      BACKGROUND:For cone beam computed tomography (CBCT), there has long been a wish to modulate the intensity and distribution of the X-rays to accommodate the patient""s anatomy as the gantry rotates from one projection to another. By doing so, both image artifacts and radiation dose would be reduced. However, the current beam modulation setups, such as dynamic bowtie filters, may be too complex for practical use in clinical applications. OBJECTIVE: This study aimed to investigate a simplified dynamic beam filtration strategy for CBCT imaging to reduce image artifacts and radiation dose. METHODS: In this study, the beam filtration was designed to vary dynamically as the gantry of the CBCT rotates around the object. Specifically, two distinct parts were integrated together: the sheet filter part and the bowtie filter part. The dynamic beam filtration setup has two working schemes, one is a combination of dynamic sheet filter and dynamic bowtie filter, denoted as dynamic filter-dynamic bowtie (DFDB); the other is a combination of dynamic sheet filter and static bowtie filter, denoted as dynamic filter-static bowtie (DFSB). Numerical imaging experiments were performed with respect to three human body parts: shoulder, chest, and knee. In addition, the Monte Carlo simulation platform MC-GPU was used to generate the dose distribution maps. RESULTS: Results showed that the use of the proposed DFDB and DFSB beam filtration schemes can significantly reduce the image artifacts and thus improve the CBCT image quality. Depending on the scanned object, the total radiation dose may be reduced by 30%. CONCLUSIONS: The proposed simple dynamic beam filtration strategy, especially the DFSB approach, might be helpful in the future to improve the CBCT image quality with reduced image artifacts and radiation dose.

    • JIANG Biao,ZHENG Jianglong,Huang Xiaoxin,Li Zhifeng,Li Linwei,HUANG Yifan

      Doi: 10.12146/j.issn.2095-3135.20241010001

      Abstract:

      Electromagnetic pulse sound source (Boomer) is a commonly used explosion sound source in marine seismic exploration, and the deep-sea application of such explosion sound source needs to solve cavitation suppression problem. In this paper, a deep-sea boomer source based on pressure compensation balance is proposed. A boomer transducer with a maximum working pressure of 20MPa is developed and tested in a high-pressure anechoic tank. Through the analysis of the hydrophone outputs under different energy and pressure levels, it can be seen that an air sac with the initial pressure of 0.5MPa can effectively balance the internal and external pressure of the transducer, solve the problem of cavitation suppression, and realize the excitation of broadband pulse sound waves. The repeatability of the acoustic wave is very good, and the minimum correlation coefficient is to 0.986. With the increase of working pressure from 0.5MPa to 20MPa, the main change in acoustic characteristics is the amplitude attenuation (204.6dB to 194.2 dB) and width compression (182μs to 88μs), and the main frequency (2.3kHz as the center) slightly shifted to high frequency. Compared with the hydrophone output in the process of pressure rising and downing in the high-pressure anechoic tank, it can be seen that the repeatability of the acoustic wave is better. The higher the pressure, the better the waveform consistency, indicating that the boomer transducer based on pressure compensation balance has a more stable performance under high pressure environment.

    • kangjianjun,niejunxi,jingjialu,changyiting,zhouwenqing,liuchaoran

      Doi: 10.12146/j.issn.2095-3135.20240828001

      Abstract:

      This article introduces a modular design concept that can realize the general observation of marine environment and multi -equipment integration of the universal marine buoyant data collection system. This system uses ARM chip timer and interrupt controller to virtually collects multi -module parallel collection processing circuits. The full system is divided into three modules: meteorological security, hydrotoma and communication according to the function of marine data buoyoma functions, and realizes the continuous collection and processing of buoyant multi -equipment, as well as real -time two -way communication. The serial extension chip realizes the system interface expansion, which improves the system"s installation capacity from the hardware. The communication module uses DMA technology to realize the functions of real -time data of dual -road real -time data, which realizes the reliable and safe operation of the buoyant system on the sea, and also improves its human -computer interaction function. This system has verified the stability, reliability, and measurement accuracy of the system through laboratory testing and operation experiments at sea.

    • zhangjiashuai,yangliuqing,fuqilin,chenghuiwu,shaocuiping,lihuiyun

      Doi: 10.12146/j.issn.2095-3135.20240914001

      Abstract:

      Chiplet-based multi-chip integration designs provide a flexible and scalable solution that surpasses traditional SoC (System on Chip) monolithic integration. However, inter-chiplet communication has become a significant bottleneck affecting overall system performance. The Network on Interposer (NoI) plays a pivotal role in multi-chip systems, directly influencing both performance and development costs. In this paper, we review NoI communication topologies for heterogeneous chiplets. We thoroughly explore the importance of current inter-chiplet communication architectures and discuss their design and implementation methods. This paper covers the entire communication process, spanning from protocol and interface layers to the application layer, classifying interconnect topologies based on their structural configurations and providing in-depth analyses and cross-comparisons for each category. Furthermore, we investigate future directions in NoI communication technologies, identifying technical challenges and potential solutions. We also propose advanced evaluation methods and modeling techniques for reusable interposer layers and topologies. This review aims to provide researchers with a thorough understanding of the current landscape and future trends in NoI technology, emphasizing its crucial role in advancing next-generation semiconductor devices across a wide spectrum of applications.

    • Zhong Jiafeng,Xu Liang,Zhou Ruiyi,Chen Bo,Zhu Yingjie,Li Lei,Xu Wei

      Doi: 10.12146/j.issn.2095-3135.20240809002

      Abstract:

      Ketamine, an N-methyl-D-aspartate receptor (NMDAR) antagonist, is clinically utilized for sedation, anesthesia, and the treatment of refractory depression. However, its addictive properties restrict its clinical application. A dose of 0.5 mg/kg is commonly used as an antidepressant in clinical settings, while 15 mg/kg represents the dose typically abused. The effects of varying doses of ketamine on brain network activation remain unclear. In this experiment, two representative doses of ketamine, 0.5 mg/kg and 15 mg/kg, were administered via intraperitoneal injection for 7 consecutive days. Brain network activation was assessed by examining the expression of the immediate early gene protein (cFos). Results indicated that, compared to the saline control group, 0.5 mg/kg ketamine significantly increased the number of cFos-positive cells in the medial prefrontal cortex, intermediate lateral septal nucleus, and periaqueductal gray matter. Conversely, 15 mg/kg ketamine significantly increased cFos expression in the nucleus accumbens, lateral habenula, hippocampal CA3 region, amygdala, and ventral tegmental area. These findings suggest that ketamine"s activation of brain networks is dose-dependent, with different doses activating distinct brain regions. This study lays a foundation for investigating the neuropharmacological effects of different ketamine doses and provides a reference for identifying brain regions associated with its antidepressant and addictive properties.

    • Duan Yulong,Hu Wei,Huang Yi,Chen Ken

      Doi: 10.12146/j.issn.2095-3135.20231030001

      Abstract:

      The usage of mmWave radar for non-contact vital signs monitoring has shown great potentials in the medical and healthcare fields, which enables continuous and imperceptible identity verification. Due to the complex impact of various factors on heart movement, the FMCW mmWave radar can better monitor and capture heart data during sleep, and the obtained heart data can be recognized and classified based on the uniqueness of personal heart movement characteristics. In this study, we propose a deep convolution neural network for identification recognition from one-dimensional time series data of the heart radar signal. The results were compared with 3 SOTA methods, i.e. LSTM, InceptionTime and LSTformer. All the models achieved classification accuracies about 90% on an experimentally acquired heart signal data set in sleep posture. The InceptionTime model has the highest accuracy, but it takes the longest time. The LSTM and LSTformer models have the lower accuracy but the shorter calculation time. The proposed CNN model can obtain similar accuracy but better efficiency in comparison with InceptionTime model.

    • Liang Zhanxiong,Sun Xudong,Cai Yonda,Zhang Yuming,Mai Langjie,He Yulin,Huang Zhexue

      Doi: 10.12146/j.issn.2095-3135.20240224001

      Abstract:

      LOGO is a new distributed computing framework using a Non-MapReduce computing paradigm. Under the LOGO framework, big data distributed computing is completed in two steps. The LO operation runs a serial algorithm in a number of nodes or virtual machines to process independently the random sample data blocks, generating local results. The GO operation uploads all local results to the master node and integrate them to obtain the approximate result of the big data set. The LOGO computing framework eliminates data communication between nodes during iterations of the algorithm, greatly improving computing efficiency, reducing memory requirements, and enhancing data scalability. This article proposes a new distributed machine learning algorithm library RSP-LOGOML under the LOGO computing framework. A new distributed computing is divided into two parts: the serial algorithm executed by the LO operation and the ensemble algorithm executed in the GO operation. The LO operation can directly execute existing serial machine learning algorithms without the need to rewrite them according to MapReduce. The GO operation executes ensemble algorithms of different kinds depending on the ensemble tasks. In this article, the principle of LOGO distributed computing is introduced first, followed by the algorithm library structure, the method for packaging existing serial algorithms and the ensemble strategy. Finally, implementation in Spark, App development, and the results of performance tests for various algorithms are demonstrated.

    • Chetali Gurung,Aamir Nawaz,Dr. U Anjaneyulu,Pei-Gen Ren

      Doi: 10.12146/j.issn.2095-3135.20231206002

      Abstract:

      The ability to mimic the microenvironment of the human body through fabrication of scaffolds itself a great achievement in the biomedical field. However, the search for the ideal scaffold is still in its infant stage and there are significant challenges to overcome. In the modern era, scientific communities are more attracted to natural substances due to their excess biological ability, low cost, biodegradability, and lesser toxic than synthetic lab made products. Chitosan is a well-known polysaccharide that has recently grabbed high amount of attention for its biological activities, especially in 3D bone tissue engineering (BTE). Chitosan greatly matches with the native tissues and thus stands out as a popular candidate for bioprinting. This review focuses on the potential of chitosan based scaffolds advancement and the drawbacks in bone treatment. Chitosan-based nanocomposites have exhibited strong mechanical strength, water-trapping ability, cellular interaction, and biodegradability characteristics. Chitosan derivatives have also encouraged and provided different routes of treatment and enhanced biological activities. 3D tailored bioprinting have opened new doors to design and manufacture scaffolds of biological, mechanical, and topographical properties.

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      • XIONG Gang,MENG Jiao,CAO Zi-gang,WANG Yong,GUO Li,FANG Bin-xing

        2012,1(1):32-42, Doi: 10.12146/j.issn.2095-3135.201205006

        Abstract:

        Nowadays, with the rapid development of the Internet, more and more new applications appear gradually, the scale of network expand constantly, and the architecture of network is more and more complicated. As one of the basic technologies for enhancing network controllability, traffic classification can not only provide better QoS for ISPs, but also supervise and manage network effectively, which can ensure the security of the Internet. In this paper we review the research methods and achievements in the field of traffic classification, compare these traditional methods, and point out their advantages and disadvantages. On the other hand, for the real challenges of real-time classification of high-speed network environment, encrypted traffic classification, fine-grained traffic classification, and dynamically changed protocols classification, we describe and analyze the related research progress. Finally, we look ahead the future research direction.

      • GE Ruiquan, WANG Pu, LI Ye,CAI Yunpeng

        2017,6(5):55-68, Doi: 10.12146/j.issn.2095-3135.201705006

        Abstract:

        Repetitive sequences are prevalent in genomes. A large number of experiments have confirmed that they play an important role in biological evolution. At present, the discovery and detection of the repetitive sequences have been becoming a hot topic of genomics. This paper summarizes the research progress in this regard, and briefly analyses the associated tools. Finally, the development of repetitive sequences in future is prospected.

      • SONG Zhang-jun

        2012,1(3):1-9, Doi: 10.12146/j.issn.2095-3135.201209001

        Abstract:

        The technology of the robot represents a national high-tech level and the degree of automation. It is helpful to develop the industry of service robots in China if we know the current situation and development trend of service robots research clearly. Recently, robotic cleaners and educational robots have been in great demand. Entertainment robots and surveillance robots are developed rapidly and the market expands quickly. Medical robots begin to enter the modern life and have played an important role in the modern surgery. To satisfy the great market and shorten the distance between China and developed countries, it is necessary to capture the development trend of the technology of service robots. R&D on service robots should focus on the integrated technologies on intelligence, modularization and network.

      • YAN Xiaoqing,CHEN Hongyun,WU Binbin,LIU Chunhua,LIANG Yan

        2015,4(4):87-93, Doi: 10.12146/j.issn.2095-3135.201504010

        Abstract:

        The human gut is densely populated by the gut microbiota. There are accumulating evidences indicating that the gut microbiota plays a significant role in the function of the body, which including the metabolism and energy absorption, the development in the function of gastrointestinal, the modulation of immune system and so on. Many chronic diseases, such as obesity, obesity-associated inflammation, inflammatory bowel disease and depression, are related to gut microbiota dysbiosis. The research of the interaction between intestinal bacteria and human body is instructive to the prevention or treatment of many chronic diseases and maintaining health.

      • ZHOU Wu,XIE Yaoqin,TIAN Yangyang

        2014,3(1):68-76, Doi: 10.12146/j.issn.2095-3135.201401007

        Abstract:

        The accurate contour delineation of the target and organs at risk (OAR) is essential in treatment planning for image guided radiation therapy. In clinical applications, the contour delineation is often done manually by clinicians, which may be accurate, but time-consuming and tedious for users. Although a lot of automatic contour delineation approaches have been proposed, few of them can fulfill the necessities of applications in terms of accuracy and efficiency. In this work, a novel approach of target delineation was proposed. Target delineation of OARs was achieved by using snake model and multiscale curve editing to obtain promising results. It allows users to quickly improve contours by a simple mouse click. Experimental results demonstrate the effectiveness of the proposed method for clinical target delineations.

      • ZHANG Wen-li

        2012,1(3):20-24, Doi: 10.12146/j.issn.2095-3135.201209004

        Abstract:

        Gene is the genetic material basis. All life phenomena, like disease and death, are related to Gene. Gene sequencing is a way to read life. With the development of new generation high-throughput sequencing technology, TB or more sequence data will be generated daily. It’s more difficult to interpret these big and complex data than to acquire them. Sequence data interpretation is a critical step in current biological research and has great practical significance. It’s a great challenge for current computer systems and computing models to store, process and analysis massive high throughput sequence data. With survey, especially from BGI (Beijing Genome Institute), the current status, problems and measures taken to process high throughput sequence data will be discussed. However, the challenge is too big to be solved unless more people in different fields work together in depth for a long term.

      • LIU Qun

        2012,1(1):48-54, Doi: 10.12146/j.issn.2095-3135.201205008

        Abstract:

        This paper gives a comprehensive introduction to the status of current machine translation research and technology, and analyzes the key problems to be resolved. Finally our idea of the future trends and prospects of machine translation are put forward.

      • ZHANG Yihong,XU Wenjing,YANG Kun

        2014,3(5):19-27, Doi: 10.12146/j.issn.2095-3135.201405003

        Abstract:

        As an advanced biosensing strategy, the electrochemical biosensor is made up of the active sensing biomaterial and the electrochemical signal transducer, and is being widely applied in the fields of clinical medicine, drug and food analysis as well as the environmental monitoring. The electrochemical biosensor has the advantages of excellent specificity, high sensitivity and simplicity. This review focused on the fundamental principle of electrochemical biosensor, its classification and the biomedical applications. The prospect of the electrochemical biosensors was outlined as well.

      • XU Guo-qing,XU Kun,LI Wei-min

        2012,1(1):6-14, Doi: 10.12146/j.issn.2095-3135.201205002

        Abstract:

        With the increasing concerns of global warming and resource constraints, electric vehicles (EVs) have made great progress during the past decade. The electric driving system of EVs has dinstinct advantages, such as quick response, easy measurement , and precise control of motor torque, available flexible driving architecture, and regenerative braking, etc. Such advantages can be used to improve the performance of vehicle dynamic control. This paper presents the recent research efforts on electric vehicle dynamic control in terms of parameters estimation and dyanmic control scheme and methodology, especially focusing on the tire-road friction estimaion , novel traction control methods. The lateral dynamic control including the electrical differential control, direct yaw moment control, and the integratin chassis cotrol is proposed. Several prospects for vehicle dynamic control are proposed.

      • WANG Hui

        2013,2(4):49-55, Doi: 10.12146/j.issn.2095-3135.201307009

        Abstract:

        Transcranial magnetic stimulation (TMS) is a non-invasive technique that can be used for brain studying and clinical therapy. Firstly, the technology feature and application of the TMS instrument were introduced. Then several TMS coil positioning methods were evaluated and several key problems about TMS coil positioning were discussed. The aim of this study was to propose a new method for TMS coil positioning. The new method combines three aspects of quantitative information including the brain scalp, brain anatomy and brain function and has great advantages and broad application prospects.

      • XIA Wei,LI Huiyun

        2017,6(3):29-40, Doi: 10.12146/j.issn.2095-3135.201703003

        Abstract:

        Automatic drive is an important application field of artificial intelligence. In this paper, a novel training strategy for self-driving vehicles was investigated based on the deep reinforcement learning model. The proposed method involves a Q-learning algorithm with filtered experience replay and pre-training with experiences from professional drivers, which accelerates the training process due to reduced exploration spaces. By resampling the input state after clustering, generalization ability of the strategy can be improved due to the individual and independent distribution of the samples. Experimental results show that, in comparison with conventional neural fitted Q-iteration algorithm, the training efficiency and controlling stability can be improved more than 90% and 30% respectively by the proposed approach. Experimental results with more complex testing tracks show that, average travel distance can be improved more than 70% in comparison with the Q-learning algorithm by the proposed method.

      • MA Xiao-yan,HONG Jue

        2012,1(3):66-71, Doi: 10.12146/j.issn.2095-3135.201209012

        Abstract:

        Hadoop job schedulers typically use a single resource abstraction and resources are allocated at the level of fixed-size partition of the nodes, called slots. These job schedulers ignore the different demands of jobs and fair allocation of multiple types of resources, leading to poor performance in throughput and average job completion time. This paper studies and implements a Muti-resource Fair Scheduler (MFS) in Hadoop. MFS adopts the idea of Dominant Resource Fairness (DRF). It uses a demand vector to describe demands for resources of a job and allocates resources to the job according to the demand vector. MFS uses resources more efficiently and satisfies multiple jobs with heterogeneous demands for resources. Experiment results show that MFS has higher throughput and shorter average job completion time compared to Hadoop slot-based Fair Scheduler and Capacity Scheduler.

      • HU Chao,SONG Shuang,YANG Wan-an,MENG Qing-hu,LI Bao-pu,ZENG De-wen,LI Xiao-xiao,ZHU Hong-mei

        2012,1(1):105-113, Doi: 10.12146/j.issn.2095-3135.201205017

        Abstract:

        Wireless Capsule Endoscope (WCE) is a very promising tool for the examination of the gastrointestinal (GI) tract. However, there are some problems to be solved for the existed WCE, and one key problem is the accurate localization and tracking of the WCE. Among the possible localization methods, the magnet-based localization technique has its advantages: no need for power, not much space occupation, continuously tracking ability, and no negative effect. In this paper, we present the localization method for the magnet objective inside the WCE based on the magnetic sensor array outside the human body. Through the algorithm and system design we realize real time tracking of 3D position and 2D orientation of the magnet based on the magnetic dipole model. In order to overcome the interference of the human body movement, we propose the multi-magnets’ localization method; also, the 3D positioning and 3D orientation method is proposed, which can be used to make the 3D recovery of the GI tract and the accurate computation of the physiological tissue parameters. The real experiments show that the proposed localization system can run well and obtain the accuracy with 2~3mm for the magnet.

      • SHEN Yang,LING Tao,YAO Hui,LI Yan-ming,JIN Qiao-feng,ZHENG Hai-rong

        2012,1(1):93-99, Doi: 10.12146/j.issn.2095-3135.201205015

        Abstract:

        For the advantages of noninvasive, real-time and quantitative detection, ultrasonic transient elastography has important clinical application value. This work investigates the transient elastography in a few ways and aims to design a transient imaging system. The Displacement tracking algorithm based on correlation techniques and the parabolic interpolation algorithm is proposed to improve the accuracy. A novel match filter is designed to convolute with the estimated displacement in the time direction to boost the SNR of the displacement for a better strain image mapping. The convoluted result shows the match filter can significantly improve the strain image quality and help getting more accurate Youngs modulus estimation. The Time Gain Compensation (TGC) circuit is designed to compensate the attenuated power of the ultrasound signal. And a modified polyacrylamide gel based tissue-mimicking phantom is also developed in this paper, both indentation testing and transient elastography are used to characterize the elastic properties of this phantom. The results are almost consistent with each other.

      • CHI Xue-bin,XIAO Hai-li,WANG Xiao-ning,CAO Rong-qiang,LU Sha-sha,ZHANG Hong-hai

        2012,1(1):68-76, Doi: 10.12146/j.issn.2095-3135.201205011

        Abstract:

        This paper introduces the scientific computing grid, ScGrid, and it’s middleware SCE. ScGrid is built as one virtual supercomputer, integrating computing resource from more than 30 institutes. It provides unified,?easy to use and reliable scientific computing services. SCE is a lightweight grid middleware, which supports global job scheduling and unified data view. It provides multiple user interfaces including command line, grid portal and APIs. At present, ScGrid has been very successfully used in Chinese Academy of Sciences and widely accepted by more than 200 users.

      • ZHANG Hao-shi,WU Zhen-xing,TIAN Lan,YANG Lin,LI Guang-lin

        2012,1(1):114-118, Doi: 10.12146/j.issn.2095-3135.201205018

        Abstract:

        Effectively reducing power line interference is always an important issue in electromyography (EMG) signal recordings and analysis. In this study, four commonly used de-noising methods, including digital notch, LMS based adaptive filter, Kalman filter and S transform, which may be suitable for the reduction of power line interference in real-time EMG recordings, were chosen and their performance in reducing the power line interference from EMG signal recordings were quantitatively analyzed and compared. The pilot results of this study showed that Kalman filter presented the best whole performance in attenuating power line interference from EMG signals and S transform de-noising method illustrated the best performance when the power line interference was severe.

      • GAO Ming,HUANG Zhe-xue

        2012,1(3):47-54, Doi: 10.12146/j.issn.2095-3135.201209009

        Abstract:

        With the rapid increase in numbers and scales of deep web sites on the Internet, search for data or information from deep web sites by submiting queries to and obtaining results from the backend databases has become a major means in information retrieval from the Web. This area has attracted many researchers to devote their efforts on development of technologies to make better use of information in th deep web. One challenge is searching for and integration of data from various databases in deep web. Since deep web is dominated by text data, research and development of technologies for text information retrieval from deep web have a broad application potential. In this paper, we review the state-of-the-art of deep web research in details and propose some future research directions.

      • LUO Li,YANG Chao,ZHAO Yu-bo,CAI Xiao-chuan

        2012,1(1):84-88, Doi: 10.12146/j.issn.2095-3135.201205013

        Abstract:

        Several of the top ranked supercomputers are based on the hybrid architecture consisting of a large number of CPUs and GPUs. High performance has been obtained for problems with special structures, such as FFT-based imaging processing or N-body based particle calculations. However, for the class of problems described by partial differential equations (PDEs) discretized by finite difference (or other mesh based methods such as finite element) methods, obtaining even reasonably good performance on a CPU/GPU cluster is still a challenge. In this paper, we propose and test an hybrid algorithm which matches the architecture of the cluster. The scalability of the approach is implemented by a domain decomposition method, and the GPU performance is realized by using a smoothed aggregation based algebraic multigrid method. Incomplete factorization, which performs beautifully on CPU but poorly on GPU, is completely avoided in the approach. Numerical experiments are carried out by using up to 32 CPU/GPUs for solving PDE problems discretized by FDM with up to 32 millions unknowns.

      • WU Zhen,ZHOU Hui,LI Guang-lin

        2013,2(4):56-60, Doi: 10.12146/j.issn.2095-3135.201307010

        Abstract:

        Foot drop is the inability to voluntarily dorsiflex the ankle during the swing phase of gait and is usually caused by weakness and damages of the peroneal nerve. The consequences of the foot drop include the decreasing of gait quality, the limiting of mobility, the increasing of falling risk, and great increasing of energy expenditure during walking. Firstly biosignal sensors are used in the drop foot stimulator to detect foot movements. Then the surface drop foot stimulator produces a predefined stimulation profile to the peroneal nerve or tibialis anterial to elicit a dorsiflexion of the foot synchronized with the swing phase of gait to lift the foot. This paper reviewed the fundamentals and current researches of drop foot stimulators. Moreover, the development trends of the closed loop drop foot stimulator were also discussed in the paper.

      • ZHAO Wen-chuang,CHENG Jun

        2012,1(3):10-14, Doi: 10.12146/j.issn.2095-3135.201209002

        Abstract:

        Human action recognition acts as an important role in human machine interaction. This paper proposes a human body recognition method from depth image based on part size and position features. Random forest classifiers are trained with different parameters. Experimental results demonstrate the feasibility of proposed approach. Recognition accuracy is about 91% and the computation time is about 0.96 us per pixel.

      Quick retrieval of articles
      • Dong Shishi, Huang Zhexue

        2012,2(1):1-7, Doi:

        Abstract:

        Random Forests is an important ensemble learning method and it is widely used in data classification and nonparametric regression. In this paper, we review three main theoretical issues of random forests, i.e., the convergence theorem, the generalization error bound and the out-of-bag estimation. In the end, we present an improved Random Forests algorithm, which uses a feature weighting sampling method to sample a subset of features at each node in growing trees. The new method is suitable to solve classification problems of very high dimensional data.

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      • Zheng Hongna, Zhu Yun, Wang LAN, Chen hui

        2017,2(1):23-28, Doi:

        Abstract:

        In order to help the hearing loss children, we obtained hearing loss children’s fallible pronunciation texts and the confusing pronunciation text pairs form a good deal of hearing loss children’s audio pronunciation data. We designed a data-driven 3D talking head articulatory animation system, it was driven by the articulatory movements which were collected from a device called Electro-magnetic articulography (EMA) AG500, the system simulated Chinese articulation realistically. In that way, the hearing loss children can observe the speaker’s lips and tongue’s motions during the speaker pronouncing, which could help the hearing loss children train pronunciation and correct the fallible pronunciations. Finally, a perception test was applied to evaluate the system’s performance. The results showed that the 3D talking head system can animate both internal and external articulatory motions effectively. A modified CM model based synthesis method was used to generate the articulatory movements. The root mean square between the real articulatory movements and synthetic articulatory movements was used to measure the synthesis method, and an average value of RMS is 1.25 mm.

        • 1
      • YU Xinjie,WU Xiongfei,Wang Jianping,CHEN Li,WANG Lei

        2012,3(5):45-51, Doi: 10.12146/j.issn.2095-3135.201405006

        Abstract:

        Morphological parameter measurement of Pseudosciaena Crocea plays an important role in its genetic selection and quality improvement. In this paper, an automatic detecting system which can measure the Pseudosciaena Crocea morphological parameters such as weight, length and body width was developed based on the machine vision and weighing sensor technology. The system can automatically detect the external morphology parameters by the machine vision, and get weight parameters through the weighing sensor. The mean errors of dimensional measurement and weighting are 0.28% and 0.74% respectively, which shows that the developed system can completely meet the requirements of morphological parameter measurement for Pseudosciaena Crocea. It is a new effective method to the automatic detection of fish morphology parameters.

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      • LIU Hengwei,LI Jianjun,XIE Xiaoyi,FANG Mou,WANG Li,HE Xiangming,OUYANG Minggao,LI Maogang

        2015,4(1):51-59, Doi: 10.12146/j.issn.2095-3135.201501007

        Abstract:

        In this work the thermal behavior of the LiNi1/3Co1/3Mn1/3O2 cathode material for soft packed lithium-ion power batteries during charging and discharging at different C-rate were conducted using the ARC (accelerating rate calorimeter) to provide an adiabatic environment. The overall heat generated by the lithium-ion battery during use, is partly reversible and partly irreversible, due to entropy change and joule heating, respectively. It indicates that the heating generation of lithium-ion cell is decided by the C-rate of charge and discharge. The heat is smaller at low C-rate of charge and discharge. For example, the heating generation of battery increases 7.16℃ at 0.2C-rate and the entropy change heat is clearly embodied. The joule heating is more remarkable than the entropy change during charging and discharging at high C-rate. For instance, the heating generation of cell increased 25.63℃ at 1C-rate. The heat generation of charge is less than discharge at the same C-rate. The DC inter insistence of cell at the SOC (State of Charge) of 0 to 10% increases suddenly, so the heating generation power will reach its maximum in this period during discharge. It is valuable for the design of heat dissipation in lithium-ion battery thermal management.

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