Abstract: High-speed aircraft belong to the future aircraft with significant disruptive significance, and energy is the key technology for high-speed aircraft. Thermoelectric power generation technology based on semiconductors is expected to achieve lightweight energy devices for high-speed aircraft. In response to the key issues of thermal/energy management for high-speed aircraft and the demands for high specific power and high specific energy, driven by the highly lightweight, integrated and integrated design requirements for structures and equipment proposed by high-speed aircraft, and based on a thorough understanding of the thermal protection of high-speed aircraft structures, considering thermoelectric devices for medium-temperature zones, under the condition of 300℃ on the hot surface, research on the integration technology of lightweight and efficient thermal insulation and heat dissipation materials and thermoelectric devices, and the integration technology of the aircraft's load-bearing structure and the cabin's active cooling system was carried out; the design of the integrated prototype scheme of the thermoelectric power generation system and the development of the principle prototype were completed, and the thermal performance test of the integrated device under the ground simulation heating environment was designed and carried out. The results show that under the condition of 300℃, the maximum output power of the thermoelectric power generation system integrated prototype is 103.9W, the maximum system conversion efficiency is 7.4%, and the stable power generation is not less than 1800s.