Abstract: Transcranial magnetic stimulation (TMS) is a non-invasive technique that can be used for brain studying and clinical therapy. Firstly, the technology feature and application of the TMS instrument were introduced. Then several TMS coil positioning methods were evaluated and several key problems about TMS coil positioning were discussed. The aim of this study was to propose a new method for TMS coil positioning. The new method combines three aspects of quantitative information including the brain scalp, brain anatomy and brain function and has great advantages and broad application prospects.