mRNA疫苗的研发历程与药物开发
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作者单位:

1.东北林业大学;2.中国科学院大学;3.能量代谢与生殖研究中心,中国科学院深圳先进技术研究院

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基金项目:

深圳市科技计划资助JCYJ20220818101218040

伦理声明:



Research and Development Course of mRNA Vaccine and Drug Development
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Ethical statement:

Affiliation:

1.School of Life Science, Northeast Foreastry University , Harbin 150006, China;2.University of Chinese Academy of Sciences, Beijing 100049, China;3.Center for Energy Metabolism and Reproduction, Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences,Shenzhen 518055, China

Funding:

Shenzhen Science and Technology Program

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    摘要:

    自SARS-CoV-2爆发以来,mRNA疫苗的开发在制药领域受到了巨大的推动并得到迅速发展。相比于其他形式的疫苗,mRNA疫苗优势明显——生产过程简单,安全性优于DNA疫苗,并且mRNA编码的抗原易于在细胞中表达,此外mRNA不需要在细胞核中转录,因此没有整合到宿主基因组的风险。然而mRNA疫苗也存在着局限性,如可能产生过敏,肾衰竭,等严重副作用,或者可能在注射后迅速降解或引起细胞因子风暴,因此解决mRNA的免疫原性以及递送效率是一个重大挑战。本文从mRNA的发展开始重点讲述了mRNA疫苗的分子设计、递送系统以及临床现状,从而为后续mRNA疫苗的发展提供一些思考。

    Abstract:

    The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to notable advancements in the pharmaceutical sector regarding the development of mRNA vaccines. These vaccines have gained considerable attention given their straightforward production process, improved safety profile compared to DNA vaccines, and efficient expression of mRNA-encoded antigens within cells. In addition, mRNA vaccines offer the advantage of not requiring transcription within the nucleus, thereby eliminating the risk of integration into the host genome. Nevertheless, mRNA vaccines also have limitations, such as possible allergy, kidney failure, and other serious side effects, or may rapidly degrade after injection or cause a cytokine storm. These factors present substantial challenges concerning the immunogenicity and delivery of mRNA vaccines. The purpose of this article is to primarily focus on the molecular design, delivery systems, and current clinical status of mRNA vaccines, aiming to provide valuable insights for future advancements in this field.

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引用本文

赵浩,柴德智,张键. mRNA疫苗的研发历程与药物开发 [J].集成技术,

Citing format
zhaohao, chaidezhi, zhangjian. Research and Development Course of mRNA Vaccine and Drug Development[J]. Journal of Integration Technology.

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  • 收稿日期:2023-01-04
  • 最后修改日期:2023-02-16
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  • 在线发布日期: 2023-05-26
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