Abstract: DNA molecules exhibit highly promising properties of high storage density and extended lifespan as a medium for next generation digital data storage. Thus, it is expected to act as an alternative to address the global issue of insufficient data storage materials. However, the current advances of DNA-based information storage are mainly focused on “the cold storage of information”, so that it is difficult to realize quick data processing in DNA, such as rewriting, updating, deleting, and erasure. Based on the current situation of “cold storage” technology, the reasons why DNA information storage media is difficult to achieve “hot storage” applications has been summarized. In that context, the data processing including destruction, encryption, rewriting, regeneration, decay, recovery, and arithmetic recording can be realized. The feasibility of using DNA media as an information processing carrier has been comprehensively demonstrated, and corresponding advantages and disadvantages were emphasized. This review aims to highlight the importance of DNA storage technology with the potential low energy consumption, high accuracy, high efficiency, and high security. Additionally, it will show the perspective regarding the integration of DNA characteristics for the next generation of intelligent information storage and processing systems.