Two dimensional turbo spin echo (2DTSE) has been the work-horse in routine MR examinations. With the combination of the slice interleaving, 2DTSE is applied to the whole brain imaging rapidly in a short time. Yet, the sampling efficiency of TSE is limited by high specific absorption rate (SAR) and strong T2 decay when it is used for 3D imaging where interleaving cannot be used. SPACE (Sampling Perfection with Application-optimized Contrasts by using different flip angle Evolutions) is a TSE variant that dramatically reduces the SAR and T2 blurring by using ultra-long echo train acquisition and non-spatially-selective refocusing RF-pulses with variable flip angles. In this paper, the basic principles of SPACE are introduced and its clinical applications are discussed.