Recent Progress in Bio-Engineered Nanoparticles for Epstein-Barr Virus Vaccines


Shenzhen Science Technology and Innovation Commission (KQTD2015033117210153, JCYJ20180302145817753)

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    Epstein-Barr virus causes a ubiquitous infection in adults worldwide. It is also a oncogenic virus that is associated with many cancers, including nasopharyngeal carcinoma which is one of the predominant tumor in South China. However, so far, a vaccine against Epstein-Barr virus was not yet available in the world and there is no effective immunotherapy against those Epstein-Barr virus associated carcinomas. With the advantages of high stability, biocompatibility, low toxicity and multifunctional regions, the nextgeneration nanoparticles has been successfully applied in the research of Epstein-Barr virus vaccines. In this article, the recent advances of nanoparticles, including exosomes, virus-like particles, self-assembling ferritin nanoparticles and other nanoparticles using for prevention and against of Epstein-Barr virus infections have been reviewed and further discussed. Finally, the opportunities and challenges faced by engineered nanoparticles in the clinical application are prospected.

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HUANG Jiandong, HUANG Kun. Recent Progress in Bio-Engineered Nanoparticles for Epstein-Barr Virus Vaccines[J]. Journal of Integration Technology,2021,10(4):67-77

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  • Online: July 26,2021
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