Application of Synthetic Biology in Promoting Preclinical and Clinical Advances of Bacterial Anti-Cancer Therapy

doi:10.12146/j.issn.2095-3135.20210427011

Home > Archive>Volume 10, Issue 4, 2021 >78-92. DOI:10.12146/j.issn.2095-3135.20210427011

Application of Synthetic Biology in Promoting Preclinical and Clinical Advances of Bacterial Anti-Cancer Therapy
DOI:
                        10.12146/j.issn.2095-3135.20210427011
                    
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                        LIU ChenliLIU Chenli
CAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China; University of Chinese Academy of Sciences, Beijing 100049, China
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DONG YuxuanDONG Yuxuan
CAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China; University of Chinese Academy of Sciences, Beijing 100049, China
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GUO XuanGUO Xuan
CAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China
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Fund Project:National Key R & D Program of China (2018YFA0902701), Strategic Priority Research Program of Chinese Academy of Sciences (XDB29050501, XDPB18), National Natural Science Foundation of China (32025022, 3201101136), Shenzhen Science Technology and Innovation Commission (KQTD2015033117210153, JCYJ20170818164139781)

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Abstract:

Bacteriotherapy is one of the important direction in the field of cancer therapy. The increasing development of synthetic biology provides more diversified, more effective and safer therapeutic strategies for bacterial anti-cancer therapy. In this review, the excellent clinical examples in the field of bacterial anti-cancer therapy are summarized, the current research progress and bottleneck problems are introduced in detail. The application of synthetic biology in promoting the clinical development of live bacterial therapeutics is also discussed. Moreover, the important role and the future development trend of synthetic biology are prospected in view of the effectiveness and biosafety of clinical live bacterial therapeutics.

Key words:synthetic biology; bacterial anti-cancer therapy; live bacterial therapeutics; clinical trials

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LIU Chenli, DONG Yuxuan, GUO Xuan. Application of Synthetic Biology in Promoting Preclinical and Clinical Advances of Bacterial Anti-Cancer Therapy[J]. Journal of Integration Technology,2021,10(4):78-92

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Online: July 26,2021
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