Abstract:Movable electrodes are important recording tools for in vivo electrophysiology in neuroscience. The traditional electrode holder supports the structure of the electrodes which can be mechanically moved. The entire electrode structure is manually assembled. During the chronic recordings, the electrode can be lowered towards deeper brain tissues so that more neurons can be recorded. However, the traditional electrode holder assembly requires multiple time-consuming steps with low-level component integration and multiple panel components are difficult to be aligned in parallel. Here, a novel eclectrode holder which consists of an intergrated design with fewer components and a stronger structues was designed. The new design reduces the differences between different electrodes and contributes to the standard experimental conditions. Simulation results show that the new electrode is resistant to deformation when the external force is applied. Compared with the traditional electrodes, the new electrode is lighter and helps reducing head loading pressure for experimental mice. Implantation of the electrode in the mouse brain demonstrates that it can obtain high-quality neural signals. Current reserach open new opportunities for improved experimental efficiency and the applications in various in vivo electrophysiology in small animals.