This work is supported by Basic and Applied Basic Research Program of Guangdong Province (2019A1515110843, 2022A1515011129), Shenzhen International Cooperation Project (GJHZ20200731095206018)
Electrical nerve stimulation is an effective method for certain treatments by affecting the central or peripheral nervous system. The instability of electrical nerve stimulation is a critical problem in clinical practice. It is a widely held view that the mechanism of the instability is that the electrical stimulation disturbs the membrane potential of nerve axons. However, due to the lack of a computable macro model for electrical nerve stimulation, it is difficult to effectively study the specific impact of its membrane potential disturbance on electrical stimulation for a long time. Based on the previously proposed circuit-probability theory, this study qualitatively analyzes the instability of electrical nerve stimulation to effectively research the influence of membrane potential disturbance on electrical stimulation. The results show that the current-instability curve of animal experimental data and qualitative simulation is highly consistent, which further indicates that the circuit-probability theory might explain the membrane potential disturbance caused by electrical stimulation and has instructive significance for the practical application of electrical nerve stimulation.
YU Shoujun, YUE Wenji, RUAN Yue, DONG Peng, CHEN Zhitong, LEE Simon Ming-yuen, SONG Bing, WANG Hao. Qualitative Analysis of Instability on Electrical Nerve Stimulation Based on Circuit-Probability Theory[J]. Journal of Integration Technology,2023,12(2):20-28Copy