Qualitative Analysis of Instability on Electrical Nerve Stimulation Based on Circuit-Probability Theory
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This work is supported by Basic and Applied Basic Research Program of Guangdong Province (2019A1515110843, 2022A1515011129), Shenzhen International Cooperation Project (GJHZ20200731095206018)

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    Abstract:

    Electrical nerve stimulation is an effective method for certain treatments by affecting the central or peripheral nervous system. The instability of electrical nerve stimulation is a critical problem in clinical practice. It is a widely held view that the mechanism of the instability is that the electrical stimulation disturbs the membrane potential of nerve axons. However, due to the lack of a computable macro model for electrical nerve stimulation, it is difficult to effectively study the specific impact of its membrane potential disturbance on electrical stimulation for a long time. Based on the previously proposed circuit-probability theory, this study qualitatively analyzes the instability of electrical nerve stimulation to effectively research the influence of membrane potential disturbance on electrical stimulation. The results show that the current-instability curve of animal experimental data and qualitative simulation is highly consistent, which further indicates that the circuit-probability theory might explain the membrane potential disturbance caused by electrical stimulation and has instructive significance for the practical application of electrical nerve stimulation.

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YU Shoujun, YUE Wenji, RUAN Yue, et al. Qualitative Analysis of Instability on Electrical Nerve Stimulation Based on Circuit-Probability Theory[J]. Journal of Integration Technology,2023,12(2):20-28

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  • Received:
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  • Online: March 23,2023
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