2023, 12(6):1-13. DOI: 10.12146/j.issn.2095-3135.20221008001
Abstract:Organic red luminogens are seriously bound by that of the energy gap law, giving rise to severe nonradiative decay of excited state and consequently low photoluminescence quantum yield (ΦPL). Herein, two red anthraquinone-based luminogens, AQ-2DPAC and AQ-2PDPAC, are synthesized by using different linking modes between the electron donor and the electron acceptor (D-A) with or without the phenyl ring as π-bridge. Their electronic structures, thermal properties, photophysical properties, and electroluminescent properties are investigated systematically to assess the impact of the phenyl bridge on their photoluminescence properties. Both highly twisted luminogens exhibit obvious aggregation-induced emission and delayed fluorescence features, and the elongation of D-A separation distance via the introduction of phenyl bridge can simultaneously decrease singlet-triplet energy splitting, enhance fluorescence decay rate and consequently increase ΦPL. Therefore, the ΦPL of D-π-A-type AQ-2PDPAC (52%) is much larger than that of D-A-type AQ-2DPAC (19%). The organic light-emitting diode employing AQ-2PDPAC as emitter realizes a high maximum external quantum efficiency of 13.7%, and a maxima luminance of 12 260 cd·m－2.
2023, 12(6):14-24. DOI: 10.12146/j.issn.2095-3135.20221010001
Abstract:Space environment can cause damage to astronauts, therefore, it is critical to monitor the physiological indicators with the purpose to study the damage mechanisms and means of protection. As a special space environments, microgravity can lead to mitochondrial dysfunction. Since mitochondrial membrane potential is an important indicator of normal mitochondria, as a result, it is meaningful to monitor mitochondrial membrane potential under simulated microgravity (SMG) quickly and easily. In this work, a mitochondria-targeting aggregation-induced emission (AIE) probe (TPE-Ph-In) is developed to monitor mitochondrial membrane potential under SMG. In order to overcome the problem of insecure cell apposition under a prolonged time of SMG, an AIE probe-hydrogel 3D imaging system is constructed by seeding the cells into Matrigel and imaging the cells with TPE-Ph-In. This work provides a new approach to investigate the cells under microgravity environment.
2023, 12(6):25-32. DOI: 10.12146/j.issn.2095-3135.20221021001
Abstract:Aggregation-induced emission molecules have been widely used in the fields of biological imaging, optical waveguide and electroluminescence due to their high luminescence efficiency, but are rarely reported in the field of optical data storage. Compared with other optical storage materials, aggregation-induced emission molecules own significant developmental advantages for super-resolution optical data storage. In this study, the possible applications in super-resolution optical data storage of the aggregation-induced molecules are discussed.
2023, 12(6):33-42. DOI: 10.12146/j.issn.2095-3135.20230413001
Abstract:Structural magnetic resonance imaging based autism spectrum disorder classification is important nowadays for early-stage screening and accurate diagnosis of autism spectrum disorder. However, due to the limitation of large data noise and small data volume, the predictive accuracy of structural magnetic resonance imaging based autism classification is not ideal. In this study, a new data augmentation model is proposed to improve classification accuracy without increasing training data volume. The University of Michigan sample 1 dataset of autism brain imaging data exchange I for autism study was used for training and evaluating the proposed model. 78 samples of the University of Michigan sample 1 dataset was selected randomly for performing the experiment, and the performance improved using proposed data augmentation algorithm for autism spectrum disorder classification task was calculated. Such a procedure was repeated for 500 times to collect results that are statistically significant. Based on the results, this method can stably improve classification accuracy between 10% and 20% in 494 out of 500 experiments (over 98% of the experiments). Through a comparative study of accuracy improvement and label change ratio, the problem of data label noise was explored.
2023, 12(6):43-56. DOI: 10.12146/j.issn.2095-3135.20230616001
Abstract:In system-on-chip (SoC) chip, due to the differences in frequencies and activities of various functional components, uneven heat generation distribution has become a serious problem, which adversely affects the reliability and overall lifespan of the chip. To address this concern, a multi-region temperature acquisition and control system for SoC chip is designed. Firstly, the on-chip bus technology is used for distributed multi-region temperature acquisition to obtain multi-region temperature information of SoC chip. Secondly, a temperature control mechanism is designed, which can both satisfy the need of both local or global temperature control. Based on the real-time data of the temperature acquisition stage, this mechanism coordinates the underclocking, interrupt, and pulse width modulation intelligent cooling system to manage and control the temperature of the chip. Additionally, users are allowed to adjust system parameters through the master control program, which makes the system compatible with various temperature control scenarios. In this study, the experiment was carried out in a large-scale multi-core SoC platform for temperature control system. The experimental results show that the proposed temperature control system can effectively slow down the chip temperature rise rate during SoC operation. Meanwhile, the maximum temperature of the chip area is controlled within the extreme high temperature critical value set by the user within the range of ±3 ℃, indicating that the temperature control system is feasible for SoC chip temperature control.
2023, 12(6):57-71. DOI: 10.12146/j.issn.2095-3135.20221020001
Abstract:The excessive glutamate-induced neuroexcitotoxicity has been widely thought as the main cause of brain cell damage in severe neurological diseases (such as ischemic stroke). Electrochemical technology is the most commonly used tool for glutamate monitoring at present. It could be applied to provide rapid and accurate assessment of the neuroexcitotoxicity for patients and animal disease models. Research advances in glutamate sensors will be important in establishing efficient therapies and brain protection strategy, and developing new drugs for severe neurological diseases. Application of nanotechnology, new enzymes, photolithography, printing, transistor technology in fabrication of glutamate sensors have greatly boosted developments in electrochemical monitoring of glutamate. In the present paper, research progress of sensing principles, design and preparation technology as well as the applications in medical studies have been reviewed, and future trends and prospective have also been discussed.
2023, 12(6):72-82. DOI: 10.12146/j.issn.2095-3135.20230313001
Abstract:Thrombin-antithrombin complex (TAT) is the product of coagulation and anticoagulation balance. Its detection reflects thrombin status and can be used as an auxiliary in the diagnosis of thrombotic diseases. A chemiluminescence immunoassay method was established to analyze TAT in human plasma samples, and its analytical performance was evaluated. The TAT was used as immunogen for monoclonal antibody preparation. TAT measurement method was established using double antibody sandwich format. After the optimization of reaction, the bulk reagent concentrations of magnetic microparticle coated with antibody and acridinium labeled antibody were 0.20 g/L and 0.2 mg/L, respectively, and the sample size was 50 μL. The reaction of magnetic particle coated antibody and sample were incubated for 5 min at 37 ℃, and 5 min for subsequent reacting with the antibody labeled with acridinium. There was no cross-reaction with samples containing 0.20 mg/mL prothrombin or 0.31 mg/mL antithrombin Ⅲ. Besides, there was a high correlation (r＞0.95) between this method and TAT test kit of Sysmex. LoB is less than or equal to 0.20 ng/mL. LoD is less than or equal to 0.40 ng/mL. The linear correlation coefficient is 0.998 in the detection interval of 0.40 to 120 ng/mL, and the accuracy is within the range of ±8%. A quantitative chemiluminescence immunoassay method for TAT measurement has been established, and the performance meets customer needs for clinical utility.
2023, 12(6):83-92. DOI: 10.12146/j.issn.2095-3135.20230402001
Abstract:Developing efficient Ni based hydrogenation catalysts to achieve the directional synthesis of 1,4-butanediol from 1,4-butynediol hydrogenation is the keypoint to building a high value extension industrial chain for coal based primary chemicals. Aiming at solving the problems of Raney Ni catalyst widely used at present, such as lacking support, low activity specific surface area, and poor hydrogenation selectivity, a Ni/ AC catalyst with well-developed pore structure activated carbon (AC) as support was prepared in this work, and the structure-activity relationship between catalyst structure and performance was discussed by combining characterization methods. The results showed that with the increase of Ni loading, the active nickel species exposed on the activated carbon surface increased at first and decreased later, and the hydrogenation activity also show as volcanic distribution. The 25% Ni/AC catalyst loaded with 25% Ni had the highest selectivity of 1,4-butanediol, reaching 86.2%. At this time, the selectivity of 1,4-butenediol and 2-hydroxytetrahydrofuran, the semi hydrogenation products, were 1.2% and 6.8%, respectively. Due to the highly dispersed active Ni species in this sample, a large amount of active hydrogen is provided, which promotes the hydrogenation reaction. Due to the long distance between Ni active centers and the low density of surface active H on catalysts with low Ni loading, isomerization side reactions are prone to occur to generate 2-hydroxytetrahydrofuran. At high Ni loading, the aggregation of Ni species results in the decrease of hydrogenation activity.
2023, 12(6):93-102. DOI: 10.12146/j.issn.2095-3135.20230406001
Abstract:Glass through-hole adapter plate is a typical vertical transmission structure widely used in threedimensional integrated package circuits. Based on the demand of radio frequency signals for the use of smalldiameter, narrow-pitch vertical vias, glass vias with a depth-to-width ratio of 8∶1 and a minimum diameter of 25.68 μm were obtained based on a photosensitive glass substrate using ultraviolet exposure, heat treatment, and wet etching methods. The mechanism of modification of photosensitive glass during the exposure process was obtained by studying the effect of exposure amount on the through-hole preparation process of photosensitive glass through-hole preparation. The experimental results show that with the increase of exposure, the throughhole aperture increases, and the photosensitive glass modification process is a gradual modification process from the front to the back side from the surface to the inside. This provides key process support for the preparation of glass through-hole adapter plates.