Affected by crosswind, vehicles under high speed are liable to deviate from the expected trajectory, which would cause higher risk of misoperation of the driver and considerable safety hazard. For the consideration of the above situation, the investigation of active control of the vehicle crosswind stability was conducted. In this research, a 3 degrees of freedom vehicle dynamic with aerodynamic force simulation model was established, a prediction controller of the vehicle crosswind stability of an active front-wheel steering vehicle was designed, and a Simulink-CarSim co-simulation platform was built for validation analysis. Results reveal that, under the working condition of unidirectional and multi-directional, the vehicle with crosswind stability controller possesses the biggest deviation value of 0.01 m, which is extremely lower than the value obtained from the vehicle without crosswind stability controller while the platform value of yaw velocity is kept around zero, and the peak value of which is reduced by 80%, which means the crosswind stability was remarkably raised.