壳聚糖:一种在三维骨组织工程中很有前途的生物活性支架材料
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1.Institute of Biomedicine and Biotechnology, Center for Energy Metabolism and Reproduction, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China;2.Institute of Chemistry, Division of Inorganic Chemistry, Islamia University of Bahawalpur, Pakistan;3.Vellore Institute of Technology, VIT, Vellore, Tamil Nadu, India

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国家自然科学基金项目(面上项目,重点项目,重大项目)

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Chitosan: A Promising Scaffold biomaterial in 3D Bone Tissue Engineering and its biological activitiess
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1.Institute of Biomedicine and Biotechnology, Center for Energy Metabolism and Reproduction, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China;2.Institute of Chemistry, Division of Inorganic Chemistry, Islamia University of Bahawalpur, Pakistan;3.Vellore Institute of Technology, VIT, Vellore, Tamil Nadu, India

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    摘要:

    通过制造支架来模拟人体微环境是生物医学领域的一大成就。然而,寻找理想生物支架的工作仍处于起步阶段,仍需要克服重大挑战。目前,天然物质对科学界有更大的吸引力,因为它们具有超强的生物能力、低成本、可生物降解性,并且比合成实验室制造的产品毒性更小。壳聚糖 (CS) 是一种著名的多糖,最近因其生物活性而备受关注,尤其是在 3D 骨组织工程 (BTE) 中。壳聚糖与天然组织非常相似,因此是生物打印的热门候选。本文重点综述了基于CS支架发展的潜力以及骨治疗的缺点。壳聚糖纳米复合材料具有较强的机械强度、吸水能力、细胞相互作用和生物降解特性。壳聚糖衍生物还提供了不同的治疗途径,并且具有较强的生物活性。 3D 定制生物打印为设计和制造具有生物、机械和地形特性的支架打开了新的大门。

    Abstract:

    The ability to mimic the microenvironment of the human body through fabrication of scaffolds itself a great achievement in the biomedical field. However, the search for the ideal scaffold is still in its infant stage and there are significant challenges to overcome. In the modern era, scientific communities are more attracted to natural substances due to their excess biological ability, low cost, biodegradability, and lesser toxic than synthetic lab made products. Chitosan is a well-known polysaccharide that has recently grabbed high amount of attention for its biological activities, especially in 3D bone tissue engineering (BTE). Chitosan greatly matches with the native tissues and thus stands out as a popular candidate for bioprinting. This review focuses on the potential of chitosan based scaffolds advancement and the drawbacks in bone treatment. Chitosan-based nanocomposites have exhibited strong mechanical strength, water-trapping ability, cellular interaction, and biodegradability characteristics. Chitosan derivatives have also encouraged and provided different routes of treatment and enhanced biological activities. 3D tailored bioprinting have opened new doors to design and manufacture scaffolds of biological, mechanical, and topographical properties.

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Chetali Gurung, Aamir Nawaz, Dr. U Anjaneyulu,等.壳聚糖:一种在三维骨组织工程中很有前途的生物活性支架材料 [J].集成技术,

Citing format
Chetali Gurung, Aamir Nawaz, Dr. U Anjaneyulu, et al. Chitosan: A Promising Scaffold biomaterial in 3D Bone Tissue Engineering and its biological activitiess[J]. Journal of Integration Technology.

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  • 收稿日期:2023-12-06
  • 最后修改日期:2023-12-06
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  • 在线发布日期: 2024-05-08
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